Figure 2

The Role of Mitochondria in Chronic Wound Healing (Mitotherapy): Signaling and Therapeutic Implications

Seyedeh Sara Azadeh* and Hoda Keshmiri Neghab

Published: 31 January, 2025 | Volume 9 - Issue 1 | Pages: 001-009

abb-aid1043-g002

Figure 2:

A model illustrating the role of mitochondrial fragmentation and reactive oxygen species (ROS) signaling in wound repair highlights the various functions of mitochondria in both single-cell closure and multicellular healing. When tissue is wounded, there is a rapid increase in cytosolic calcium (Ca²⁺) due to external influx or internal release, which triggers mitochondrial fragmentation through the actions of DRP-1 or MIRO-1. In response to this calcium increase, fragmented mitochondria enhance the production of mtROS, aiding in the closure of the actin ring in single-cell systems. Additionally, mtROS may support multicellular wound healing by participating in processes such as angiogenesis and inflammation [42]. 

Read Full Article HTML DOI: 10.29328/journal.abb.1001043 Cite this Article Read Full Article PDF

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